Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge

BACKGROUND: Xenobiotics are primarily metabolized by hepatocytes in the liver, and primary human hepatocytes are the gold standard model for the assessment of drug efficacy, safety, and toxicity in the early phases of drug development. Recent advances in single-cell genomics demonstrate liver zonati...

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Detalles Bibliográficos
Autores principales: Sanchez-Quant, Eva, Richter, Maria Lucia, Colomé-Tatché, Maria, Martinez-Jimenez, Celia Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583437/
https://www.ncbi.nlm.nih.gov/pubmed/37848949
http://dx.doi.org/10.1186/s13059-023-03075-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583437/
https://www.ncbi.nlm.nih.gov/pubmed/37848949
http://dx.doi.org/10.1186/s13059-023-03075-9

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