An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates

In contrast to the checkerboard method, bactericidal experiments [time-kill curves (TKCs)] allow an assessment of pharmacodynamic (PD) interactions over time. However, TKCs in combination pose interpretation problems. The objective of this study was to characterize the PD interaction over time betwe...

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Detalles Bibliográficos
Autores principales: Aubry, Romain, Buyck, Julien, Prouvensier, Laure, Decousser, Jean-Winoc, Nordmann, Patrice, Wicha, Sebastian G., Marchand, Sandrine, Grégoire, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583682/
https://www.ncbi.nlm.nih.gov/pubmed/37681977
http://dx.doi.org/10.1128/aac.00301-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583682/
https://www.ncbi.nlm.nih.gov/pubmed/37681977
http://dx.doi.org/10.1128/aac.00301-23

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