An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates

In contrast to the checkerboard method, bactericidal experiments [time-kill curves (TKCs)] allow an assessment of pharmacodynamic (PD) interactions over time. However, TKCs in combination pose interpretation problems. The objective of this study was to characterize the PD interaction over time betwe...

Descripción completa

Detalles Bibliográficos
Autores principales: Aubry, Romain, Buyck, Julien, Prouvensier, Laure, Decousser, Jean-Winoc, Nordmann, Patrice, Wicha, Sebastian G., Marchand, Sandrine, Grégoire, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583682/
https://www.ncbi.nlm.nih.gov/pubmed/37681977
http://dx.doi.org/10.1128/aac.00301-23

Ejemplares similares

Ejemplares similares