A palladium catalyzed asymmetric desymmetrization approach to enantioenriched 1,3-disubstituted isoindolines

Herein, we report the first palladium/MPAA catalyzed enantioselective C–H activation/[4 + 1] annulation of diarylmethyltriflamide and olefins to construct chiral cis-1,3-disubstituted isoindoline derivatives. The use of a readily accessible mono-N-protected amino acid as a chiral ligand improves the...

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Detalles Bibliográficos
Autores principales: Dethe, Dattatraya H., Kumar, Vimlesh, Shukla, Manmohan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583692/
https://www.ncbi.nlm.nih.gov/pubmed/37860662
http://dx.doi.org/10.1039/d3sc03496h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583692/
https://www.ncbi.nlm.nih.gov/pubmed/37860662
http://dx.doi.org/10.1039/d3sc03496h

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