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A palladium catalyzed asymmetric desymmetrization approach to enantioenriched 1,3-disubstituted isoindolines

Herein, we report the first palladium/MPAA catalyzed enantioselective C–H activation/[4 + 1] annulation of diarylmethyltriflamide and olefins to construct chiral cis-1,3-disubstituted isoindoline derivatives. The use of a readily accessible mono-N-protected amino acid as a chiral ligand improves the...

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Detalles Bibliográficos
Autores principales:	Dethe, Dattatraya H., Kumar, Vimlesh, Shukla, Manmohan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583692/ https://www.ncbi.nlm.nih.gov/pubmed/37860662 http://dx.doi.org/10.1039/d3sc03496h

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