Calculation-assisted regioselective functionalization of the imidazo[1,2-a]pyrazine scaffold via zinc and magnesium organometallic intermediates

Straightforward calculations such as determinations of pK(a) values and N-basicities have allowed the development of a set of organometallic reactions for the regioselective functionalization of the underexplored fused N-heterocycle imidazo[1,2-a]pyrazine. Thus, regioselective metalations of 6-chlor...

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Detalles Bibliográficos
Autores principales: Kastrati, Agonist, Kremsmair, Alexander, Sunagatullina, Alisa S., Korotenko, Vasilii, Guersoy, Yusuf C., Rout, Saroj K., Lima, Fabio, Brocklehurst, Cara E., Karaghiosoff, Konstantin, Zipse, Hendrik, Knochel, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583695/
https://www.ncbi.nlm.nih.gov/pubmed/37860644
http://dx.doi.org/10.1039/d3sc02893c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583695/
https://www.ncbi.nlm.nih.gov/pubmed/37860644
http://dx.doi.org/10.1039/d3sc02893c

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