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From random to rational: improving enzyme design through electric fields, second coordination sphere interactions, and conformational dynamics

Enzymes are versatile and efficient biological catalysts that drive numerous cellular processes, motivating the development of enzyme design approaches to tailor catalysts for diverse applications. In this perspective, we investigate the unique properties of natural, evolved, and designed enzymes, r...

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Detalles Bibliográficos
Autores principales: Chaturvedi, Shobhit S., Bím, Daniel, Christov, Christo Z., Alexandrova, Anastassia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583697/
https://www.ncbi.nlm.nih.gov/pubmed/37860658
http://dx.doi.org/10.1039/d3sc02982d