The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)

The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are therapeutic targets for diseases such as cancer, neurodegeneration and immunological disorders as they are key components in regulating cell signalling pathways. In an effort to make probe molecules available for further exploring these ta...

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Detalles Bibliográficos
Autores principales: Aldred, Gregory G., Rooney, Timothy P. C., Willems, Henriette M. G., Boffey, Helen K., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583824/
https://www.ncbi.nlm.nih.gov/pubmed/37859710
http://dx.doi.org/10.1039/d3md00355h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583824/
https://www.ncbi.nlm.nih.gov/pubmed/37859710
http://dx.doi.org/10.1039/d3md00355h

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