Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes

CONTEXT: Lost glucagon-like peptide 1 receptor (GLP-1R) function affects human physiology. OBJECTIVE: This work aimed to identify coding nonsynonymous GLP1R variants in Danish individuals to link their in vitro phenotypes and clinical phenotypic associations. METHODS: We sequenced GLP1R in 8642 Dani...

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Detalles Bibliográficos
Autores principales: Melchiorsen, Josefine U, Sørensen, Kimmie V, Bork-Jensen, Jette, Kizilkaya, Hüsün S, Gasbjerg, Lærke S, Hauser, Alexander S, Rungby, Jørgen, Sørensen, Henrik T, Vaag, Allan, Nielsen, Jens S, Pedersen, Oluf, Linneberg, Allan, Hartmann, Bolette, Gjesing, Anette P, Holst, Jens J, Hansen, Torben, Rosenkilde, Mette M, Grarup, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Clinical Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584003/
https://www.ncbi.nlm.nih.gov/pubmed/37235780
http://dx.doi.org/10.1210/clinem/dgad290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584003/
https://www.ncbi.nlm.nih.gov/pubmed/37235780
http://dx.doi.org/10.1210/clinem/dgad290

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