Machine learning approach to evaluate TdP risk of drugs using cardiac electrophysiological model including inter-individual variability

Introduction: Predicting ventricular arrhythmia Torsade de Pointes (TdP) caused by drug-induced cardiotoxicity is essential in drug development. Several studies used single biomarkers such as qNet and Repolarization Abnormality (RA) in a single cardiac cell model to evaluate TdP risk. However, a sin...

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Detalles Bibliográficos
Autores principales: Fuadah, Yunendah Nur, Qauli, Ali Ikhsanul, Marcellinus, Aroli, Pramudito, Muhammad Adnan, Lim, Ki Moo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584148/
https://www.ncbi.nlm.nih.gov/pubmed/37860622
http://dx.doi.org/10.3389/fphys.2023.1266084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584148/
https://www.ncbi.nlm.nih.gov/pubmed/37860622
http://dx.doi.org/10.3389/fphys.2023.1266084

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