Global lactylome reveals lactylation-dependent mechanisms underlying T(H)17 differentiation in experimental autoimmune uveitis

Dysregulation of CD4(+) T cell differentiation is linked to autoimmune diseases. Metabolic reprogramming from oxidative phosphorylation to glycolysis and accumulation of lactate are involved in this process. However, the underlying mechanisms remain unclear. Our study showed that lactate-derived lac...

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Detalles Bibliográficos
Autores principales: Fan, Wei, Wang, Xiaotang, Zeng, Shuhao, Li, Na, Wang, Guoqing, Li, Ruonan, He, Siyuan, Li, Wanqian, Huang, Jiaxing, Li, Xingran, Liu, Jiangyi, Hou, Shengping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584346/
https://www.ncbi.nlm.nih.gov/pubmed/37851814
http://dx.doi.org/10.1126/sciadv.adh4655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584346/
https://www.ncbi.nlm.nih.gov/pubmed/37851814
http://dx.doi.org/10.1126/sciadv.adh4655

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