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Probing conformational dynamics to understand kinase inhibition
Why do some inhibitors select the on-state in ERK2, a kinase that is involved in many signaling pathways in cells, whereas others bind to more than one conformation?
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584368/ https://www.ncbi.nlm.nih.gov/pubmed/37850630 http://dx.doi.org/10.7554/eLife.92753 |