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High-content microscopy reveals a morphological signature of bortezomib resistance

Drug resistance is a challenge in anticancer therapy. In many cases, cancers can be resistant to the drug prior to exposure, that is, possess intrinsic drug resistance. However, we lack target-independent methods to anticipate resistance in cancer cell lines or characterize intrinsic drug resistance...

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Detalles Bibliográficos
Autores principales: Kelley, Megan E, Berman, Adi Y, Stirling, David R, Cimini, Beth A, Han, Yu, Singh, Shantanu, Carpenter, Anne E, Kapoor, Tarun M, Way, Gregory P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584373/
https://www.ncbi.nlm.nih.gov/pubmed/37753907
http://dx.doi.org/10.7554/eLife.91362