Brazilin from Caesalpinia sappan L. as a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor: Pharmacophore-Based Virtual Screening, In Silico Molecular Docking, and In Vitro Studies

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial regulator of low-density lipoprotein cholesterol (LDL-c) levels, as it binds to and degrades the LDL receptor (LDLR) in the lysosome of hepatocytes. Elevated levels of PCSK9 have been linked to an increased LDL-c plasma l...

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Detalles Bibliográficos
Autores principales: Iqbal, Muhammad, Hasanah, Nur, Arianto, Aimee Detria, Aryati, Widya Dwi, Puteri, Meidi Utami, Saputri, Fadlina Chany
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584496/
https://www.ncbi.nlm.nih.gov/pubmed/37860715
http://dx.doi.org/10.1155/2023/5932315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584496/
https://www.ncbi.nlm.nih.gov/pubmed/37860715
http://dx.doi.org/10.1155/2023/5932315

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