Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants

Despite the prominent role of the K-Ras protein in many different types of human cancer, major gaps in atomic-level information severely limit our understanding of its functions in health and disease. Here, we report the quantitative backbone structural dynamics of K-Ras by solution nuclear magnetic...

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Detalles Bibliográficos
Autores principales: Hansen, Alexandar L., Xiang, Xinyao, Yuan, Chunhua, Bruschweiler-Li, Lei, Brüschweiler, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584678/
https://www.ncbi.nlm.nih.gov/pubmed/37640864
http://dx.doi.org/10.1038/s41594-023-01070-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584678/
https://www.ncbi.nlm.nih.gov/pubmed/37640864
http://dx.doi.org/10.1038/s41594-023-01070-z

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