Inhibition of fatty acid oxidation enables heart regeneration in adult mice

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle, instating a barrier for adult heart regeneration(1,2). Here, to explore whether metabolic reprogramming can overcome this bar...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Wu, Fan, Günther, Stefan, Looso, Mario, Kuenne, Carsten, Zhang, Ting, Wiesnet, Marion, Klatt, Stephan, Zukunft, Sven, Fleming, Ingrid, Poschet, Gernot, Wietelmann, Astrid, Atzberger, Ann, Potente, Michael, Yuan, Xuejun, Braun, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584682/
https://www.ncbi.nlm.nih.gov/pubmed/37758950
http://dx.doi.org/10.1038/s41586-023-06585-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584682/
https://www.ncbi.nlm.nih.gov/pubmed/37758950
http://dx.doi.org/10.1038/s41586-023-06585-5

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