Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2

Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and can be targeted to treat neuropsychiatric and neurological disorders, including epilepsy. Here we present cryogenic-electron micr...

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Detalles Bibliográficos
Autores principales: Gangwar, Shanti Pal, Yen, Laura Y., Yelshanskaya, Maria V., Korman, Aryeh, Jones, Drew R., Sobolevsky, Alexander I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584687/
https://www.ncbi.nlm.nih.gov/pubmed/37653241
http://dx.doi.org/10.1038/s41594-023-01080-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584687/
https://www.ncbi.nlm.nih.gov/pubmed/37653241
http://dx.doi.org/10.1038/s41594-023-01080-x

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