Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq

Thymic T cell development comprises T cell receptor (TCR) recombination and assessment of TCR avidity towards self-peptide-MHC complexes presented by antigen-presenting cells. Self-reactivity may lead to negative selection, or to agonist selection and differentiation into unconventional lineages suc...

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Detalles Bibliográficos
Autores principales: Heimli, Marte, Tennebø Flåm, Siri, Sagsveen Hjorthaug, Hanne, Bjørnstad, Pål Marius, Chernigovskaya, Maria, Le, Quy Khang, Tekpli, Xavier, Greiff, Victor, Lie, Benedicte Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584817/
https://www.ncbi.nlm.nih.gov/pubmed/37853083
http://dx.doi.org/10.1038/s41598-023-44693-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584817/
https://www.ncbi.nlm.nih.gov/pubmed/37853083
http://dx.doi.org/10.1038/s41598-023-44693-4

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