Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggregated form, which accumulates in the brain of PD pat...

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Detalles Bibliográficos
Autores principales: Sastre, Danuta, Zafar, Faria, Torres, C. Alejandra Morato, Piper, Desiree, Kirik, Deniz, Sanders, Laurie H., Qi, L. Stanley, Schüle, Birgitt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584834/
https://www.ncbi.nlm.nih.gov/pubmed/37853101
http://dx.doi.org/10.1038/s41598-023-45078-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584834/
https://www.ncbi.nlm.nih.gov/pubmed/37853101
http://dx.doi.org/10.1038/s41598-023-45078-3

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