Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions

Vascular endothelial cadherin (VE-cadherin) expressed at endothelial adherens junctions (AJs) is vital for vascular integrity and endothelial homeostasis. Here we identify the requirement of the ubiquitin E3-ligase CHFR as a key mechanism of ubiquitylation-dependent degradation of VE-cadherin. CHFR...

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Detalles Bibliográficos
Autores principales: Tiruppathi, Chinnaswamy, Wang, Dong-Mei, Ansari, Mohammad Owais, Bano, Shabana, Tsukasaki, Yoshikazu, Mukhopadhyay, Amitabha, Joshi, Jagdish C., Loch, Christian, Niessen, Hans W. M., Malik, Asrar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584835/
https://www.ncbi.nlm.nih.gov/pubmed/37852964
http://dx.doi.org/10.1038/s41467-023-42225-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584835/
https://www.ncbi.nlm.nih.gov/pubmed/37852964
http://dx.doi.org/10.1038/s41467-023-42225-2

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