Adeno-associated viral capsid stability on anion exchange chromatography column and its impact on empty and full capsid separation

Recombinant adeno-associated viral vector (rAAV) mediated gene therapy is gaining traction in treating genetic disorders. Current rAAV production systems yield a mixture of capsids largely devoid of the transgene (empty capsid) compared with the desired therapeutic product (full capsid). Anion excha...

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Detalles Bibliográficos
Autores principales: Khanal, Ohnmar, Kumar, Vijesh, Jin, Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585339/
https://www.ncbi.nlm.nih.gov/pubmed/37868210
http://dx.doi.org/10.1016/j.omtm.2023.101112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585339/
https://www.ncbi.nlm.nih.gov/pubmed/37868210
http://dx.doi.org/10.1016/j.omtm.2023.101112

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