Cargando…

Microsponge-derived mini tablets loaded with immunosuppressive agents: Pharmacokinetic investigation in human volunteers, cell viability and IVIVC correlation

Sirolimus, a potent immunosuppressant, has been demonstrated to have remarkable activity in inhibiting allograft rejection in transplantation. The objective of the study was to fabricate microsponge mini tablets with enhanced solubility and bioavailability. β-Cyclodextrin and NEOCEL C91 were selecte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mehmood, Yasir, Shahid, Hira, Abbas, Muhammad, Farooq, Umar, Ali, Shaukat, Kazi, Mohsin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585343/ https://www.ncbi.nlm.nih.gov/pubmed/37868642 http://dx.doi.org/10.1016/j.jsps.2023.101799

Ejemplares similares

Microsponge-Based Gel Loaded with Immunosuppressant as a Simple and Valuable Strategy for Psoriasis Therapy: Determination of Pro-Inflammatory Response through Cytokine IL-2 mRNA Expression
por: Mehmood, Yasir, et al.
Publicado: (2023)

IVIVC for Extended Release Hydrophilic Matrix Tablets in Consideration of Biorelevant Mechanical Stress
por: Mohylyuk, Valentyn, et al.
Publicado: (2020)

Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis
por: He, Yeteng, et al.
Publicado: (2020)

Dendrimer entrapped microsponge gel of dithranol for effective topical treatment
por: Tripathi, Pushpendra Kumar, et al.
Publicado: (2019)

Developing of SiO(2) Nanoshells Loaded with Fluticasone Propionate for Potential Nasal Drug Delivery: Determination of Pro-Inflammatory Cytokines through mRNA Expression
por: Mehmood, Yasir, et al.
Publicado: (2022)

IVIVC from Long Acting Olanzapine Microspheres
por: D'Souza, Susan, et al.
Publicado: (2014)

Establishment of Level a In Vitro–In Vivo Correlation (IVIVC) via Extended DoE-IVIVC Model: A Donepezil Case Study
por: Lee, Da Young, et al.
Publicado: (2022)

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions
por: Margolskee, Alison, et al.
Publicado: (2015)

Microsponges for dermatological applications: Perspectives and challenges
por: Mahant, Sheefali, et al.
Publicado: (2020)

Novel Hydrolytic Degradable Crosslinked Interpenetrating Polymeric Networks (IPNs): An Efficient Hybrid System to Manage the Controlled Release and Degradation of Misoprostol
por: Mehmood, Yasir, et al.
Publicado: (2023)

Microsponges: A novel strategy for drug delivery system
por: Kaity, Santanu, et al.
Publicado: (2010)

Ocular administration of acetazolamide microsponges in situ gel formulations
por: Obiedallah, Manar M., et al.
Publicado: (2018)

Factors Contributing to Drug Release From Enteric-Coated Omeprazole Capsules: An In Vitro and In Vivo Pharmacokinetic Study and IVIVC Evaluation in Beagle Dogs
por: Cui, Cheng, et al.
Publicado: (2020)

IVIVC Assessment of Two Mouse Brain Endothelial Cell Models for Drug Screening
por: Puscas, Ina, et al.
Publicado: (2019)

Preparation and In Vitro-In Vivo Evaluation of Luteolin Loaded Gastroretentive Microsponge for the Eradication of Helicobacter pylori Infections
por: Jafar, Mohammed, et al.
Publicado: (2021)

Amikacin-Loaded Chitosan Hydrogel Film Cross-Linked with Folic Acid for Wound Healing Application
por: Mehmood, Yasir, et al.
Publicado: (2023)

Formulation and Evaluation of Optimized Oxybenzone Microsponge Gel for Topical Delivery
por: Pawar, Atmaram P., et al.
Publicado: (2015)

Formulation and evaluation of curcumin microsponges for oral and topical drug delivery
por: Bhatia, Meenakshi, et al.
Publicado: (2018)

Optimization of entrapment efficiency and release of clindamycin in microsponge based gel
por: KHATTAB, ALAA, et al.
Publicado: (2021)

Impact of porous microsponges in minimizing myotoxic side effects of simvastatin
por: Ali, Ahmed U., et al.
Publicado: (2023)

Development of apigenin loaded gastroretentive microsponge for the targeting of Helicobacter pylori
por: Jafar, Mohammed, et al.
Publicado: (2023)

Physiologically Relevant In Vitro-In Vivo Correlation (IVIVC) Approach for Sildenafil with Site-Dependent Dissolution
por: Kim, Tae Hwan, et al.
Publicado: (2019)

Evaluating the bioequivalence of two pitavastatin calcium formulations based on IVIVC modeling and clinical study
por: Wang, Jiaying, et al.
Publicado: (2022)

Developing Nanosuspension Loaded with Azelastine for Potential Nasal Drug Delivery: Determination of Proinflammatory Interleukin IL-4 mRNA Expression and Industrial Scale-Up Strategy
por: Mehmood, Yasir, et al.
Publicado: (2023)

Pharmacokinetic Properties of Single- and Multiple-Dose Pitavastatin Calcium Tablets in Healthy Chinese Volunteers
por: Luo, Zhu, et al.
Publicado: (2015)

Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers
por: Kwak, Seong Shin, et al.
Publicado: (2018)

Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy
por: Moin, Afrasim, et al.
Publicado: (2016)

Microsponges based novel drug delivery system for augmented arthritis therapy
por: Osmani, Riyaz Ali M., et al.
Publicado: (2015)

Nanoporous Microsponge Particles (NMP) of Polysaccharides as Universal Carriers for Biomolecules Delivery
por: Caso, Maria Federica, et al.
Publicado: (2020)

Screening of Adapalene Microsponges Fabrication Parameters with Insight on the In vitro Biological Effectiveness
por: Yehia, Rania M, et al.
Publicado: (2022)

Pharmacokinetics and Bioequivalence Study of Hydroxychloroquine Sulfate Tablets in Chinese Healthy Volunteers by LC–MS/MS
por: Fan, Hong-wei, et al.
Publicado: (2015)

Pharmaceutical and pharmacokinetic characterization of a novel sublingual buprenorphine/naloxone tablet formulation in healthy volunteers
por: Fischer, Andreas, et al.
Publicado: (2015)

Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques
por: Chen, Mo, et al.
Publicado: (2013)

Tableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting properties and tablet dimensions
por: Lura, Ard, et al.
Publicado: (2020)

Fabrication and Characterization of Sertaconazole Nitrate Microsponge as a Topical Drug Delivery System
por: Pande, V. V., et al.
Publicado: (2015)

Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges
por: Zaman, Muhammad, et al.
Publicado: (2018)

Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC
por: Basiri, Babak, et al.
Publicado: (2020)

Development and validation of an in vitro–in vivo correlation (IVIVC) model for propranolol hydrochloride extended-release matrix formulations
por: Cheng, Chinhwa, et al.
Publicado: (2013)

In Vitro–In Vivo Correlations (IVIVC) for Predicting the Clinical Performance of Metronidazole Topical Creams Intended for Local Action
por: Rath, Seeprarani, et al.
Publicado: (2023)

Bioequivalence and Pharmacokinetic Evaluation Study of Acetaminophen vs. Acetaminophen Plus Caffeine Tablets in Healthy Mexican Volunteers
por: Guzmán, Nora Angélica Núñez, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_luafkm19dk2qjab1as7lljfbjo