Loss of Non-motor Kinesin KIF26A Causes Congenital Brain Malformations via Dysregulated Neuronal Migration and Axonal Growth as well as Apoptosis

Kinesins are canonical molecular motors but can also function as modulators of intracellular signaling. KIF26A, an unconventional kinesin that lacks motor activity, inhibits growth factor receptor bound protein 2 (GRB2)- and focal adhesion kinase (FAK)-dependent signal transduction, but its function...

Descripción completa

Detalles Bibliográficos
Autores principales: Qian, Xuyu, DeGennaro, Ellen M., Talukdar, Maya, Akula, Shyam K., Lai, Abbe, Shao, Diane D., Gonzalez, Dilenny, Marciano, Jack H., Smith, Richard S., Hylton, Norma K., Yang, Edward, Bazan, J. Fernando, Barrett, Lee, Yeh, Rebecca C., Hill, R Sean, Beck, Samantha, Otani, Aoi, Angad, Jolly, Mitani, Tadahiro, Posey, Jennifer E., Pehlivan, Davut, Calame, Daniel, Aydin, Hatip, Yesilbas, Osman, Parks, Kendall C., Argilli, Emanuela, England, Eleina, Im, Kiho, Taranath, Ajay, Scott, Hamish S., Barnett, Christopher P., Arts, Peer, Sherr, Elliott H., Lupski, James R., Walsh, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585591/
https://www.ncbi.nlm.nih.gov/pubmed/36228617
http://dx.doi.org/10.1016/j.devcel.2022.09.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585591/
https://www.ncbi.nlm.nih.gov/pubmed/36228617
http://dx.doi.org/10.1016/j.devcel.2022.09.011

Ejemplares similares