Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold

A novel library of human carbonic anhydrase (hCA) inhibitors based on the 2-sulfanilamido[1,2,4]triazolo[1,5-a]pyrimidine skeleton modified at its 7-position was prepared by an efficient convergent procedure. These derivatives were evaluated in vitro for their inhibition properties against a represe...

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Detalles Bibliográficos
Autores principales: Romagnoli, Romeo, De Ventura, Tiziano, Manfredini, Stefano, Baldini, Erika, Supuran, Claudiu T., Nocentini, Alessio, Brancale, Andrea, Bortolozzi, Roberta, Manfreda, Lorenzo, Viola, Giampietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586084/
https://www.ncbi.nlm.nih.gov/pubmed/37850364
http://dx.doi.org/10.1080/14756366.2023.2270180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586084/
https://www.ncbi.nlm.nih.gov/pubmed/37850364
http://dx.doi.org/10.1080/14756366.2023.2270180

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