Identification, Synthesis, and Characterization of Potential Oxidative Impurities of Venetoclax: Application of Meisenheimer Rearrangement

[Image: see text] Venetoclax is a potent BCL-2 inhibitor that is used for the treatment of several blood cancers. During the oxidative stress degradation of venetoclax, we observed the formation of two potential impurities at levels of about 8–10%, which have similar molecular weights. The two impur...

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Detalles Bibliográficos
Autores principales: Vaddamanu, Guruswamy, Goswami, Anandarup, Nandipati, Ravi Shekar Reddy, Malireddy, Yamini Tanuja, Katam Reddy, Vinod Kumar Reddy, Mulakayala, Naveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586452/
https://www.ncbi.nlm.nih.gov/pubmed/37867659
http://dx.doi.org/10.1021/acsomega.3c05325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586452/
https://www.ncbi.nlm.nih.gov/pubmed/37867659
http://dx.doi.org/10.1021/acsomega.3c05325

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