Cargando…

Identification, Synthesis, and Characterization of Potential Oxidative Impurities of Venetoclax: Application of Meisenheimer Rearrangement

[Image: see text] Venetoclax is a potent BCL-2 inhibitor that is used for the treatment of several blood cancers. During the oxidative stress degradation of venetoclax, we observed the formation of two potential impurities at levels of about 8–10%, which have similar molecular weights. The two impur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vaddamanu, Guruswamy, Goswami, Anandarup, Nandipati, Ravi Shekar Reddy, Malireddy, Yamini Tanuja, Katam Reddy, Vinod Kumar Reddy, Mulakayala, Naveen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586452/ https://www.ncbi.nlm.nih.gov/pubmed/37867659 http://dx.doi.org/10.1021/acsomega.3c05325

Ejemplares similares

Identification, Synthesis, and Characterization of Novel Baricitinib Impurities
por: Vaddamanu, Guruswamy, et al.
Publicado: (2023)

Stereospecific Asymmetric Synthesis of Tertiary Allylic Alcohol Derivatives by Catalytic [2,3]‐Meisenheimer Rearrangements
por: Yu, Xin, et al.
Publicado: (2020)

Stable Spirocyclic Meisenheimer Complexes
por: Al-Kaysi, Rabih O., et al.
Publicado: (2008)

Synthesis and Characterization of Impurities in the Production Process of Lopinavir
por: Raghava Reddy, Ambati V., et al.
Publicado: (2015)

On-line Ammonia Sensor and Invisible Security Ink by Fluorescent Zwitterionic Spirocyclic Meisenheimer Complex
por: Das, Tanmay, et al.
Publicado: (2017)

Fluorescent “Turn-Off” Detection of Fluoride and Cyanide Ions Using Zwitterionic Spirocyclic Meisenheimer Compounds
por: Benet, Marina, et al.
Publicado: (2017)

Development of RP-HPLC, Stability Indicating Method for Degradation Products of Linagliptin in Presence of Metformin HCl by Applying 2 Level Factorial Design; and Identification of Impurity-VII, VIII and IX and Synthesis of Impurity-VII
por: Jadhav, Sushant B., et al.
Publicado: (2017)

Cost-Effective Isolation of a Process Impurity of Pregabalin
por: Prakash, Lakkireddy, et al.
Publicado: (2015)

Glutathione Peroxidase of Pennisetum glaucum (PgGPx) Is a Functional Cd(2+) Dependent Peroxiredoxin that Enhances Tolerance against Salinity and Drought Stress
por: Islam, Tahmina, et al.
Publicado: (2015)

CRISPR-Cas9 mediated mutation in GRAIN WIDTH and WEIGHT2 (GW2) locus improves aleurone layer and grain nutritional quality in rice
por: Achary, V. Mohan Murali, et al.
Publicado: (2021)

Experimental Analyses Emphasize the Stability of the Meisenheimer Complex in a S(N)Ar Reaction Toward Trends in Reaction Pathways
por: Campodónico, Paola R., et al.
Publicado: (2020)

Synthesis, isolation, identification and characterization of new process-related impurity in isoproterenol hydrochloride by HPLC, LC/ESI-MS and NMR
por: Kumar, Neeraj, et al.
Publicado: (2017)

Evaluating the clinical and esthetic outcome of apically positioned flap technique in augmentation of keratinized gingiva around dental implants
por: Reddy, Vineela Katam, et al.
Publicado: (2013)

Identification and Characterization of Potential Impurities in Raloxifene Hydrochloride
por: Reddy, Reguri Buchi, et al.
Publicado: (2012)

Kodai School on ‘Synthesis of Elements in Stars’
por: Goswami, Aruna, et al.
Publicado: (2010)

Role of miRNA-155 in the regulation of osteoclast differentiation mediated by MITF in stage III/IV periodontitis: a case-control study
por: Nandipati, Sowmya Reddy, et al.
Publicado: (2022)

Controlled chemoselective defluorination and non-defluorination for [5 + 1] aromatic annulation via Meisenheimer-type nitrogen anion and radical intermediates
por: Qian, Jinlong, et al.
Publicado: (2019)

Thermal rearrangement of tert-butylsulfinamide
por: Arava, Veera Reddy, et al.
Publicado: (2011)

Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate
por: Awasthi, Arun Kumar, et al.
Publicado: (2019)

Expression of Pennisetum glaucum Eukaryotic Translational Initiation Factor 4A (PgeIF4A) Confers Improved Drought, Salinity, and Oxidative Stress Tolerance in Groundnut
por: Santosh Rama Bhadra Rao, Tata, et al.
Publicado: (2017)

Rhodium catalyzed diastereoselective synthesis of 2,2,3,3-tetrasubstituted indolines from N-sulfonyl-1,2,3-triazoles and ortho-vinylanilines
por: Yadagiri, Dongari, et al.
Publicado: (2016)

Synthesis of RP 48497, an Impurity of Eszopiclone
por: Sha, Yu, et al.
Publicado: (2008)

Structural modelling and phylogenetic analyses of PgeIF4A2 (Eukaryotic translation initiation factor) from Pennisetum glaucum reveal signature motifs with a role in stress tolerance and development
por: Agarwal, Aakrati, et al.
Publicado: (2016)

Imperfections and impurities in semiconductor silicon
por: Ravi, K V
Publicado: (1981)

Systematic Approach for Trace Level Quantification of 2-N-butyl-4-spirocyclopentane-2-imidazole-5-one Genotoxic Impurity in Irbesartan Using LC-MS/MS
por: Reddy, A. Vijaya Bhaskar, et al.
Publicado: (2013)

Venetoclax-containing regimens in acute myeloid leukemia
por: Aldoss, Ibrahim, et al.
Publicado: (2021)

Complexity in Estimation of Esomeprazole and its Related Impurities’ Stability in Various Stress Conditions in Low-Dose Aspirin and Esomeprazole Magnesium Capsules
por: Reddy, Palavai Sripal, et al.
Publicado: (2013)

Low flow vascular malformation of the buccal mucosa treated conservatively by sclerotherapy (3% sodium tetradecyl sulfate)
por: Candamourty, Ramesh, et al.
Publicado: (2012)

Evidence revealing the role of T cell regulators (Tregs) in periodontal diseases: A review
por: Ilango, Paavai, et al.
Publicado: (2021)

Transcriptional Downregulation of Rice rpL32 Gene under Abiotic Stress Is Associated with Removal of Transcription Factors within the Promoter Region
por: Mukhopadhyay, Pradipto, et al.
Publicado: (2011)

Efficient carbon-Ferrier rearrangement on glycals mediated by ceric ammonium nitrate: Application to the synthesis of 2-deoxy-2-amino-C-glycoside
por: Ansari, Alafia A, et al.
Publicado: (2014)

Combined Ruxolitinib and Venetoclax Treatment in a Patient with a BCR-JAK2 Rearranged Myeloid Neoplasm
por: Lap, Coen J., et al.
Publicado: (2021)

Novel Compounds Synergize With Venetoclax to Target KMT2A-Rearranged Pediatric Acute Myeloid Leukemia
por: Tregnago, Claudia, et al.
Publicado: (2022)

Notes on a visit to Kurt G. Lahr, Idar-Oberstein and to Conrad & Co., Meisenheim and Sobernheim (Germany) on the 6th and 7th May 1986
por: Cornuet, D
Publicado: (1986)

Synthesis, Characterization and Quantification of Simvastatin Metabolites and Impurities
por: Bhatia, Manish S., et al.
Publicado: (2011)

Impure Water Makes Impure Ice
Publicado: (1882)

Thermally Induced Hydrogen-Bond Rearrangements in Small Water Clusters and the Persistent Water Tetramer
por: Samala, Nagaprasad Reddy, et al.
Publicado: (2019)

Development of stable transgenic maize plants tolerant for drought by manipulating ABA signaling through Agrobacterium-mediated transformation
por: Muppala, Sridevi, et al.
Publicado: (2021)

Data Set For Computation Of Maxillary Arch Perimeter With Ramanujan's Equation For Ellipse In Different Skeletal Malocclusions.
por: Singaraju, Gowri Sankar, et al.
Publicado: (2020)

Evaluation of the Pharmaceutical Quality of Docetaxel Injection Using New Stability Indicating Chromatographic Methods for Assay and Impurities
por: Malleswara Reddy, Annarapu, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_68h6rpkgphda6l4pl5ucbbo39j