Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice

Goldenseal is a perennial plant native to eastern North America. A recent clinical study reported goldenseal decreased metformin C(max) and area under the blood concentration versus time curve (AUC) by 27% and 23%, respectively, but half-life and renal clearance were unchanged. These observations su...

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Detalles Bibliográficos
Autores principales: Oyanna, Victoria O., Garcia-Torres, Kenisha Y., Bechtold, Baron J., Lynch, Katherine D., Call, M. Ridge, Horváth, Miklós, Manwill, Preston K., Graf, Tyler N., Cech, Nadja B., Oberlies, Nicholas H., Paine, Mary F., Clarke, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586506/
https://www.ncbi.nlm.nih.gov/pubmed/37562957
http://dx.doi.org/10.1124/dmd.123.001360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586506/
https://www.ncbi.nlm.nih.gov/pubmed/37562957
http://dx.doi.org/10.1124/dmd.123.001360

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