Incorporation of inosine into DNA by human polymerase eta (Polη): kinetics of nucleotide misincorporation and structural basis for the mutagenicity

Inosine, a purine nucleoside containing the hypoxanthine (HX) nucleobase, can form in DNA via hydrolytic deamination of adenine. Due to its structural similarity to guanine and the geometry of Watson–Crick base pairs, inosine can mispair with cytosine upon catalysis by DNA polymerases, leading to AT...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Tretyakova, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586757/
https://www.ncbi.nlm.nih.gov/pubmed/37746864
http://dx.doi.org/10.1042/BCJ20230159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586757/
https://www.ncbi.nlm.nih.gov/pubmed/37746864
http://dx.doi.org/10.1042/BCJ20230159

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