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New insights into the mechanochemical coupling mechanism of kinesin–microtubule complexes from their high-resolution structures

Kinesin motor proteins couple mechanical movements in their motor domain to the binding and hydrolysis of ATP in their nucleotide-binding pocket. Forces produced through this ‘mechanochemical’ coupling are typically used to mobilize kinesin-mediated transport of cargos along microtubules or microtub...

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Detalles Bibliográficos
Autores principales: Benoit, Matthieu P.M.H., Hunter, Byron, Allingham, John S., Sosa, Hernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586761/
https://www.ncbi.nlm.nih.gov/pubmed/37560910
http://dx.doi.org/10.1042/BST20221238