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The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches
Of the many genetic alterations that occur in cancer, relatively few have proven to be suitable for the development of targeted therapies. Mutations in isocitrate dehydrogenase (IDH) 1 and -2 increase the capacity of cancer cells to produce a normally scarce metabolite, D-2-hydroxyglutarate (2-HG),...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Portland Press Ltd.
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586776/ https://www.ncbi.nlm.nih.gov/pubmed/37526143 http://dx.doi.org/10.1042/BST20230017 |