Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity

Metabolic reprogramming, including increased glucose uptake and lactic acid excretion, is a hallmark of cancer. The glycolytic ‘gatekeeper’ enzyme phosphofructokinase-1 (PFK1), which catalyzes the step committing glucose to breakdown, is dysregulated in cancers. While altered PFK1 activity and expre...

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Detalles Bibliográficos
Autores principales: Voronkova, Maria A., Hansen, Heather L., Cooper, Madison P., Miller, Jacob, Sukumar, Narayanasami, Geldenhuys, Werner J., Robart, Aaron R., Webb, Bradley A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586780/
https://www.ncbi.nlm.nih.gov/pubmed/37622331
http://dx.doi.org/10.1042/BCJ20230207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586780/
https://www.ncbi.nlm.nih.gov/pubmed/37622331
http://dx.doi.org/10.1042/BCJ20230207

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