Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

Cytotoxic CD8 +T lymphocytes (CTLs) are key players of adaptive anti-tumor immunity based on their ability to specifically recognize and destroy tumor cells. Many cancer immunotherapies rely on unleashing CTL function. However, tumors can evade killing through strategies which are not yet fully eluc...

Descripción completa

Detalles Bibliográficos
Autores principales: Herzfeldt, Ann-Kathrin, Gamez, Marta Puig, Martin, Eva, Boryn, Lukasz Miloslaw, Baskaran, Praveen, Huber, Heinrich J, Schuler, Michael, Park, John E, Swee, Lee Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586807/
https://www.ncbi.nlm.nih.gov/pubmed/37732732
http://dx.doi.org/10.7554/eLife.84314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586807/
https://www.ncbi.nlm.nih.gov/pubmed/37732732
http://dx.doi.org/10.7554/eLife.84314

Ejemplares similares