SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury

BACKGROUND: Sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) is a key protein that maintains myocardial Ca(2+) homeostasis. The present study aimed to investigate the mechanism underlying the SERCA2a-SUMOylation (small ubiquitin-like modifier) process after ischemia/reperfusion injury (I/RI) in vi...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Yuanyuan, Zhou, Shuaishuai, Xu, Tao, Wu, Wanling, Shang, Pingping, Wang, Shuai, Pan, Defeng, Li, Dongye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586866/
https://www.ncbi.nlm.nih.gov/pubmed/37462038
http://dx.doi.org/10.1097/CM9.0000000000002757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586866/
https://www.ncbi.nlm.nih.gov/pubmed/37462038
http://dx.doi.org/10.1097/CM9.0000000000002757

Ejemplares similares