Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2

Selenoprotein P (SeP) is a major selenoprotein in serum predominantly produced in the liver. Excess SeP impairs insulin secretion from the pancreas and insulin sensitivity in skeletal muscle, thus inhibition of SeP could be a therapeutic strategy for type 2 diabetes. In this study, we examine the ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Xinying, Toyama, Takashi, Taguchi, Keiko, Arisawa, Kotoko, Kaneko, Takayuki, Tsutsumi, Ryouhei, Yamamoto, Masayuki, Saito, Yoshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587141/
https://www.ncbi.nlm.nih.gov/pubmed/37857700
http://dx.doi.org/10.1038/s42003-023-05449-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587141/
https://www.ncbi.nlm.nih.gov/pubmed/37857700
http://dx.doi.org/10.1038/s42003-023-05449-y

Ejemplares similares