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Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2
Selenoprotein P (SeP) is a major selenoprotein in serum predominantly produced in the liver. Excess SeP impairs insulin secretion from the pancreas and insulin sensitivity in skeletal muscle, thus inhibition of SeP could be a therapeutic strategy for type 2 diabetes. In this study, we examine the ef...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587141/ https://www.ncbi.nlm.nih.gov/pubmed/37857700 http://dx.doi.org/10.1038/s42003-023-05449-y |