Ligand activation mechanisms of human KCNQ2 channel

The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize the membrane potential. KCNQ2 can be activated by analgesics and antiepileptic drugs but their activation mechanisms remain unclear. Here we report cryo-electron microscopy (cryo-EM) struct...

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Detalles Bibliográficos
Autores principales: Ma, Demin, Zheng, Yueming, Li, Xiaoxiao, Zhou, Xiaoyu, Yang, Zhenni, Zhang, Yan, Wang, Long, Zhang, Wenbo, Fang, Jiajia, Zhao, Guohua, Hou, Panpan, Nan, Fajun, Yang, Wei, Su, Nannan, Gao, Zhaobing, Guo, Jiangtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587151/
https://www.ncbi.nlm.nih.gov/pubmed/37857637
http://dx.doi.org/10.1038/s41467-023-42416-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587151/
https://www.ncbi.nlm.nih.gov/pubmed/37857637
http://dx.doi.org/10.1038/s41467-023-42416-x

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