Transporter modulation of molnupiravir and its metabolite β-D-N4-hydroxycytidine across the blood-brain barrier in a rat

BACKGROUND: The antiviral drug molnupiravir is an orally bioavailable prodrug of the nucleoside analog β-D-N4-hydroxycytidine (NHC), which is used to treat coronavirus disease 2019 (COVID-19). However, there is very little information on the barrier distribution of molnupiravir. Our hypothesis is th...

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Detalles Bibliográficos
Autores principales: Chang, Chun-Hao, Peng, Wen-Ya, Lee, Wan-Hsin, Yang, Ling, Lin, Tung-Yi, Yang, Muh-Hwa, Tsai, Tung-Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587300/
https://www.ncbi.nlm.nih.gov/pubmed/37857815
http://dx.doi.org/10.1038/s43856-023-00383-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587300/
https://www.ncbi.nlm.nih.gov/pubmed/37857815
http://dx.doi.org/10.1038/s43856-023-00383-w

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