Sequential Early-Life Infections Alter Peripheral Blood Transcriptomics in Aging Female Mice but Not the Response to De Novo Infection with Influenza Virus or M. tuberculosis

To determine the impact of accumulating Ag exposure on immunity in the aging mouse, and to develop a model more relevant to humans who are exposed to multiple pathogens during life, we sequentially infected young female mice with four distinct pathogens at 8-wk intervals: murine γ-herpesvirus 68, Se...

Descripción completa

Detalles Bibliográficos
Autores principales: Lanzer, Kathleen G., Cookenham, Tres, Lehrmann, Elin, Zhang, Yongqing, Duso, Debbie, Xie, Qingqing, Reiley, William W., Becker, Kevin G., Blackman, Marcia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2023
Materias:
Adaptive Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587504/
https://www.ncbi.nlm.nih.gov/pubmed/37555847
http://dx.doi.org/10.4049/immunohorizons.2200066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587504/
https://www.ncbi.nlm.nih.gov/pubmed/37555847
http://dx.doi.org/10.4049/immunohorizons.2200066

Ejemplares similares