Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor function

Acute anemia elicits broad transcriptional changes in erythroid progenitors and precursors. We previously discovered a cis-regulatory transcriptional enhancer at the sterile alpha motif domain-14 enhancer locus (S14E), defined by a CANNTG-spacer-AGATAA composite motif and occupied by GATA1 and TAL1...

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Detalles Bibliográficos
Autores principales: Zhou, Yichao, Dogiparthi, Venkatasai Rahul, Ray, Suhita, Schaefer, Meg A., Harris, Hannah L., Rowley, M. Jordan, Hewitt, Kyle J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Red Cells, Iron, and Erythropoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587717/
https://www.ncbi.nlm.nih.gov/pubmed/36809789
http://dx.doi.org/10.1182/bloodadvances.2022009163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587717/
https://www.ncbi.nlm.nih.gov/pubmed/36809789
http://dx.doi.org/10.1182/bloodadvances.2022009163

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