NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration

BACKGROUND: Neovascular age-related macular degeneration causes vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Cx3cr1(−/−) mice display alterations in non-classical monocytes and microglia with increased CNV size, suggesting that non-classical monocytes may inh...

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Detalles Bibliográficos
Autores principales: Droho, Steven, Voigt, Andrew P., Sterling, Jacob K., Rajesh, Amrita, Chan, Kyle S., Cuda, Carla M., Perlman, Harris, Lavine, Jeremy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588116/
https://www.ncbi.nlm.nih.gov/pubmed/37858232
http://dx.doi.org/10.1186/s12974-023-02928-1

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