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IGF-1R targeting in cancer – does sub-cellular localization matter?

The insulin-like growth factor receptor (IGF-1R) was among the most intensively pursued kinase targets in oncology. However, even after a slew of small-molecule and antibody therapeutics reached clinical trials for a range of solid tumors, the initial promise remains unfulfilled. Mechanisms of resis...

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Detalles Bibliográficos
Autores principales: Soni, Upendra K., Jenny, Liam, Hegde, Rashmi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588251/
https://www.ncbi.nlm.nih.gov/pubmed/37858153
http://dx.doi.org/10.1186/s13046-023-02850-7