Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability

Costimulation serves as a critical checkpoint for T-cell activation, and several genetic variants affecting costimulatory pathways confer risk for autoimmune diseases. A single nucleotide polymorphism (rs763361) in the CD226 gene encoding a costimulatory receptor increases susceptibility to multiple...

Descripción completa

Detalles Bibliográficos
Autores principales: Thirawatananond, Puchong, Brown, Matthew E., Sachs, Lindsey K., Arnoletti, Juan M., Yeh, Wen-I, Posgai, Amanda L., Shapiro, Melanie R., Chen, Yi-Guang, Brusko, Todd M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2023
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588280/
https://www.ncbi.nlm.nih.gov/pubmed/37625150
http://dx.doi.org/10.2337/db23-0307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588280/
https://www.ncbi.nlm.nih.gov/pubmed/37625150
http://dx.doi.org/10.2337/db23-0307

Ejemplares similares