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Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability

Costimulation serves as a critical checkpoint for T-cell activation, and several genetic variants affecting costimulatory pathways confer risk for autoimmune diseases. A single nucleotide polymorphism (rs763361) in the CD226 gene encoding a costimulatory receptor increases susceptibility to multiple...

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Detalles Bibliográficos
Autores principales:	Thirawatananond, Puchong, Brown, Matthew E., Sachs, Lindsey K., Arnoletti, Juan M., Yeh, Wen-I, Posgai, Amanda L., Shapiro, Melanie R., Chen, Yi-Guang, Brusko, Todd M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2023
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588280/ https://www.ncbi.nlm.nih.gov/pubmed/37625150 http://dx.doi.org/10.2337/db23-0307

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