Germline landscape of RPA1, RPA2 and RPA3 variants in pediatric malignancies: identification of RPA1 as a novel cancer predisposition candidate gene

Replication Protein A (RPA) is single-strand DNA binding protein that plays a key role in the replication and repair of DNA. RPA is a heterotrimer made of 3 subunits – RPA1, RPA2, and RPA3. Germline pathogenic variants affecting RPA1 were recently described in patients with Telomere Biology Disorder...

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Detalles Bibliográficos
Autores principales: Sharma, Richa, Oak, Ninad, Chen, Wenan, Gogal, Rose, Kirschner, Martin, Beier, Fabian, Schnieders, Michael J., Spies, Maria, Nichols, Kim E., Wlodarski, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588448/
https://www.ncbi.nlm.nih.gov/pubmed/37869077
http://dx.doi.org/10.3389/fonc.2023.1229507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588448/
https://www.ncbi.nlm.nih.gov/pubmed/37869077
http://dx.doi.org/10.3389/fonc.2023.1229507

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