Simultaneous determination of tramadol and paracetamol in human plasma using LC-MS/MS and application in bioequivalence study of ­fixed-dose combination

The study aimed to develop a sensitive and high-throughput liquid chromatography coupled with tandem mass spectrometry method to quantify concentrations of tramadol and paracetamol simultaneously in human plasma. Sample preparation involved single-step protein precipitation using methanol and two de...

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Detalles Bibliográficos
Autores principales: Loh, Gabriel Onn Kit, Wong, Emily Yii Ling, Goh, Chen Zhu, Tan, Yvonne Tze Fung, Lee, Yi Lin, Pang, Lai Hui, Shahridzo, Siti Halimah, Damenthi, Nair, Hermansyah, Andi, Long, Chiau Ming, Peh, Kok Khiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588528/
https://www.ncbi.nlm.nih.gov/pubmed/37857359
http://dx.doi.org/10.1080/07853890.2023.2270502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588528/
https://www.ncbi.nlm.nih.gov/pubmed/37857359
http://dx.doi.org/10.1080/07853890.2023.2270502

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