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Microglial WNT5A supports dendritic spines maturation and neuronal firing

There is increasing evidence showing that microglia play a critical role in mediating synapse formation and spine growth, although the molecular mechanism remains elusive. Here, we demonstrate that the secreted morphogen WNT family member 5A (WNT5A) is the most abundant WNT expressed in microglia an...

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Detalles Bibliográficos
Autores principales: Yeh, Hana, Woodbury, Maya E., Ingraham Dixie, Kaitlin L., Ikezu, Tsuneya, Ikezu, Seiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588768/
https://www.ncbi.nlm.nih.gov/pubmed/36395958
http://dx.doi.org/10.1016/j.bbi.2022.11.003