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Transepithelial Barrier Dysfunction Drives Microbiota Dysbiosis to Initiate Epithelial Clock-driven Inflammation

BACKGROUND: Factors that contribute to inflammatory bowel disease [IBD] pathogenesis include genetic polymorphisms, barrier loss, and microbial dysbiosis. A major knowledge gap exists in the origins of the colitogenic microbiome and its relationship with barrier impairment. Epithelial myosin light c...

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Detalles Bibliográficos
Autores principales: Pai, Yu-Chen, Li, Yi-Hsuan, Turner, Jerrold R, Yu, Linda Chia-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588795/
https://www.ncbi.nlm.nih.gov/pubmed/37004200
http://dx.doi.org/10.1093/ecco-jcc/jjad064