Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release

Virus-induced changes in host lipid metabolism are an important but poorly understood aspect of viral pathogenesis. By combining nontargeted lipidomics analyses of infected cells and purified extracellular quasi-enveloped virions with high-throughput RNA sequencing and genetic depletion studies, we...

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Detalles Bibliográficos
Autores principales: Shiota, Tomoyuki, Li, Zhucui, Chen, Guan-Yuan, McKnight, Kevin L., Shirasaki, Takayoshi, Yonish, Bryan, Kim, Heyjeong, Fritch, Ethan J., Sheahan, Timothy P., Muramatsu, Masamichi, Kapustina, Maryna, Cameron, Craig E., Li, You, Zhang, Qibin, Lemon, Stanley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588952/
https://www.ncbi.nlm.nih.gov/pubmed/37862421
http://dx.doi.org/10.1126/sciadv.adj4198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588952/
https://www.ncbi.nlm.nih.gov/pubmed/37862421
http://dx.doi.org/10.1126/sciadv.adj4198

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