Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells

PURPOSE: MYC-driven Group 3 medulloblastoma (MB) (subtype II) is a highly aggressive childhood brain tumor. Sensitivity of MYC-driven MB to class I histone deacetylase inhibitors (HDACi) has been previously demonstrated in vitro and in vivo. In this study we characterize the transcriptional effects...

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Detalles Bibliográficos
Autores principales: Vollmer, Johanna, Ecker, Jonas, Hielscher, Thomas, Valinciute, Gintvile, Ridinger, Johannes, Jamaladdin, Nora, Peterziel, Heike, van Tilburg, Cornelis M., Oehme, Ina, Witt, Olaf, Milde, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589189/
https://www.ncbi.nlm.nih.gov/pubmed/37783879
http://dx.doi.org/10.1007/s11060-023-04445-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589189/
https://www.ncbi.nlm.nih.gov/pubmed/37783879
http://dx.doi.org/10.1007/s11060-023-04445-w

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