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Primate-specific isoform of Nedd4-1 regulates substrate binding via Ser/Thr phosphorylation and 14-3-3 binding
Nedd4 (Nedd4-1) is an E3 ubiquitin ligase involved in crucial biological processes such as growth factor receptor signaling. While canonical Nedd4-1 comprises a C2-WW((4))-HECT domain architecture, alternative splicing produces non-canonical isoforms that are poorly characterized. Here we characteri...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589272/ https://www.ncbi.nlm.nih.gov/pubmed/37863970 http://dx.doi.org/10.1038/s41598-023-44761-9 |